ibalizumab for multidrug-resistant hiv-1

and now, a fascinating new study published in the new england journal of medicine entitled phase 3 study of ibalizumab for multidrug-resistant hiv-1.  ibalizumab, a humanized igg4 monoclonal antibody, blocks the entry of hiv-1 by noncompetitive binding to cd4. besides the obvious issues of cost and long-term safety outcomes, i wonder about the why the study was 25 weeks long. why not 26 weeks or 50 … Continue reading ibalizumab for multidrug-resistant hiv-1

brilliant work by marjorie pritchard and ellen clegg

in my opinion, marjorie pritchard and ellen clegg at the boston globe are doing brilliant work with their campaign, ‘journalists are not the enemy.’ “i choose my friends for their good looks, my acquaintances for their good characters, and my enemies for their intellects. A man cannot be too careful in the choice of his enemies.” — oscar wilde what do you think? please leave a … Continue reading brilliant work by marjorie pritchard and ellen clegg

economic tumult in turkey: worries of “contagion”

economic tumult in turkey: worries of contagion erdogan’s widening grip trips up efforts to stem crisis by carlotta gall, new york times istanbul – president recep tayyip erdogan has long made clear that he considered no part of turkish life beyond his reach, not least the economy. even before he was re-elected in june with sultan-like powers, he had built his popularity on sustained economic … Continue reading economic tumult in turkey: worries of “contagion”

my patient’s faithful sisters

in the new york times yesterday, helen ouyang m.d., wrote an essay entitled, my patient’s faithful sisters, about a patient in a persistent vegetative state coming into the emergency department, and her sisters. the essay was lovely, and i was left wanting more, particularly about the “characters.” the “taller sister,” with her “curly hair cut into a triangular bob,” and the “smaller sister.” but who are these women, … Continue reading my patient’s faithful sisters

in france, even the rats have rights

french freedom fighters press for the rights of parisian rats rodents, overrunning the city of light, have their defenders; ‘rat-prochement’ vive la resistance! “we really need to find a balance to live together.” – claudine duperret and now, a comedic front-page article in the wall street journal, regarding the 4 million rats overrunning paris, and their “defenders,” people who are trying to save the lives … Continue reading in france, even the rats have rights