Drug-resistant TB is an enormous public health threat. Please join the NEJM online forum on TB transmission I am co-moderating with Ruvandhi Nathavithara. The forum was stimulated by the paper published by Shah et al. on XDR-TB transmission in KwaZulu Natal, South Africa. This important study used a mixture of genotyping methods: IS6110RFLP, targeted gene sequencing and whole genome sequencing with social network analysis to demonstrate that the majority of XDR-TB cases in KwaZulu Natal occurred due to primary transmission rather than acquired drug resistance.
Mimì, the heroine of Puccini’s opera, La bohème, suffers from tuberculosis.