Whole-genome sequencing identifies nosocomial transmission of extra-pulmonary MTB

Hospital infection control practice reflects the working assumption that extra pulmonary TB is not considered infectious. A recent case report from Oxford, UK described how whole-genome sequencing identified the nosocomial transmission of extra-pulmonary MTB infection.

The patient had “an immune reconstitution like-syndrome with suppurating lymph nodes requiring daily dressing whilst remaining culture positive for 3 weeks.”

Aerosol generation during dressing changes was most likely the source of the TB transmission, given the less-than-impressive Chest CT scan.

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